*******************************************
* Glycosyl hydrolases family 16 signature *
*******************************************

It has been shown [1] that  the following  glycosyl hydrolases can be, on the
basis of sequence similarities, classified into a single family:

 - Bacterial  beta-1,3-1,4-glucanases  (EC 3.2.1.73) (lichenases), mainly from
   Bacillus but  also  from  Clostridium  thermocellum  (gene  licB)  and from
   Fibrobacter succinogenes.
 - Bacillus criculans beta-1,3-glucanase A1 (EC 3.2.1.39) (gene glcA).
 - Lamarinase (EC 3.2.1.6) from Clostridium thermocellum (gene lam1).

Two closely clustered conserved  glutamate  have  been  shown [2], in Bacillus
licheniformis lichenase, to be involved in the catalytic activity.  We use the
regions that contains these residues as a signature pattern.

-Consensus pattern: E-[LIV]-D-[LIV]-x(0,1)-E-x(2)-G-[KRN]-x-[PST]
                    [The two E's are active site residues]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: NONE.

-Expert(s) to contact by email: Henrissat B.
                                bernie@cermav.grenet.fr

-Last update: June 1994 / First entry.

[ 1] Henrissat B.
     Biochem. J. 280:309-316(1991).
[ 2] Juncosa M., Pons J., Dot T., Querol E., Planas A.
     J. Biol. Chem. 269:14530-14535(1994).