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* Epimorphin family signature *
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The following proteins have been shown to be evolutionary related [1,2,3]:

 - Epimorphin,  a  mammalian mesenchymal protein which plays an essential role
   in epithelial morphogenesis.
 - Syntaxin  A (also known as antigen HPC-1) and syntaxin B which are synaptic
   proteins which   may  be  involved  in  docking  of  synaptic  vesicles  at
   presynaptic active zones.
 - Yeast  PEP12  which  is  required  for  the  transport  of proteases to the
   vacuole.
 - Yeast  SED5 which is required for the fusion of transport vesicles with the
   Golgi complex.
 - Yeast SSO1 and SSO2  which are  required for vesicle fusion with the plasma
   membrane.

The above  proteins  share  the following characteristics: a size ranging from
30 Kd  to  40  Kd;  a  C-terminal extremity which is highly hydrophobic and is
probably involved  in  anchoring  the protein to the membrane; a central, well
conserved region, which seems to be in a coiled-coil conformation.

The pattern specific for  this family is based on the most conserved region of
the coiled coil domain.

-Consensus pattern: R-x(3)-[LIVM]-x(2)-[LIVM]-E-x(2)-[LIVM]-x-E-[LIVM]-x(2)-
                    [LIVM]-F-x(2)-[LIVM]-x(2)-[LIVMF]-V-x(2)-Q-[GQ]-x(2)-
                    [LIVM]-[DNQ]-x-[LIVM]-[DE]-x-N
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Last update: October 1993 / First entry.

[ 1] Spring J., Kato M., Bernfield M.
     Trends Biochem. Sci. 18:124-125(1993).
[ 2] Pelham H.R.B.
     Cell 73:425-426(1993).
[ 3] Aalto M., Ronne H., Keraenen S.
     EMBO J. 11:4095-4104(1993).