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* Bacterial type II secretion system protein E signature *
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A number  of  bacterial  proteins,  some  of  which  are involved in a general
secretion pathway  (GSP) for the export  of  proteins (also called the type II
pathway) [1,2],  have  been  found to be evolutionary related.  These proteins
are listed below:

 - The  'E'  protein from the GSP operon of: Aeromonas hydrophila (gene exeE);
   Erwinia chrysanthemi  and  carotovora  (gene  outE);  Klebsiella pneumoniae
   (gene pulE); Pseudomonas aeruginosa (gene xcpR); Vibrio cholera (gene epsE)
   and Xanthomonas campestris (gene xpsE).
 - Agrobacterium tumefaciens Ti plasmid virB operon protein 11.  This  protein
   is required for the transfer of T-DNA to plants.
 - Bacillus subtilis comG operon protein 1 which is required for the uptake of
   DNA by competent Bacillus subtilis cells.
 - Pseudomonas aeruginosa protein pilB,  which  is essential for the formation
   of the pili.
 - Pseudomonas aeruginosa protein twitching mobility protein pilT.
 - Neisseria gonorrhoeae type IV pilus assembly protein pilF.
 - Vibrio cholerae tcp pilus secretion protein tcpF.
 - Escherichia coli protein hopB.

These proteins have from 344 (pilT and virB11) to 566 (pilB) amino acids, they
are probably  cytoplasmically located and, on  the  basis of the presence of a
conserved P-loop region, probably bind ATP. As a signature pattern we selected
a region that overlaps the 'B' motif of ATP-binding proteins.

-Consensus pattern: [LIVM]-R-x(2)-P-D-x-[LIVM](3)-G-E-[LIVM]-R-D
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Last update: June 1994 / Text revised.

[ 1] Salmond G.P.C., Reeves P.J.
     Trends Biochem. Sci. 18:7-12(1993).
[ 3] Hobbs M., Mattick J.S.
     Mol. Microbiol. 10:233-243(1993).