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* SRF-type transcription factors DNA-binding and dimerization domain *
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A number of transcription factors  contain a conserved domain of 56 amino-acid
residues, sometimes known as the MADS-domain. They are listed below:

 - The serum response factor (SRF) [1], a mammalian  transcription factor that
   binds to the Serum Response Element (SRE). This is a short sequence of dyad
   symmetry located 300 bp  to the 5' end of the transcription initiation site
   of genes such as c-fos.
 - Yeast  GRM/PRTF  protein  (gene  MCM1) [2], a  transcriptional regulator of
   mating-type-specific genes.
 - Yeast arginine metabolism regulation protein I (gene ARGR1 or ARG80).
 - Arabidopsis thaliana  agamous  protein (AG) [3],  a  probable transcription
   factor  involved  in  regulating  genes  that  determines stamen and carpel
   development in wild-type flowers.   Mutations in  the AG gene result in the
   replacement of the stamens by petals and the carpels by a new flower.
 - Arabidopsis  thaliana  homeotic  proteins Apetala1 (AP1) and Apetala3 (AP3)
   which act  locally  to  specify the identity of the floral meristem  and to
   determine sepal and petal development [4].
 - Antirrhinum majus and tobacco homeotic protein deficiens (DEFA) and globosa
   (GLO) [5].  Both proteins are transcription factors involved in the genetic
   control of  flower  development.    Mutations  in  DEFA  or  GLO  cause the
   transformation of petals into sepals and of stamina into carpels.
 - Arabidopsis thaliana putative transcription factors AGL1 to AGL6 [6].
 - Antirrhinum majus morphogenetic protein DEF H33 (squamosa).

In SRF, the conserved domain has been shown [1] to  be involved in DNA-binding
and dimerization.  We have derived a pattern that spans the complete length of
the domain.

-Consensus pattern: R-x-[RK]-x(5)-I-[DE]-N-x(3)-R-x(2)-T-[FY]-x-[RK](3)-x(2)-
                    [LIVM]-x-K(2)-A-x-E-[LIVM]-[ST]-x-L-x(4)-[LIVM]-x-
                    [LIVM](3)-x(6)-[LIVM]-x(2)-[FY]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Last update: June 1994 / Pattern and text revised.

[ 1] Norman C., Runswick M., Pollock R., Treisman R.
     Cell 55:989-1003(1988).
[ 2] Passmore S., Maine G.T., Elble R., Christ C., Tye B.K.
     J. Mol. Biol. 204:593-606(1988).
[ 3] Yanofsky M., Ma H., Bowman J., Drews G., Feldmann K.A., Meyerowitz E.M.
     Nature 346:35-39(1990).
[ 4] Mandel A., Gustafson-Brown C., Savidge B., Yanofsky M.
     Nature 360:273-277(1992).
[ 5] Troebner W., Ramirez L., Motte P., Hue I., Huijser P., Loennig W.-E.,
     Saedler H., Sommer H., Schwartz-Sommer Z.
     EMBO J. 11:4693-4704(1992).
[ 6] Ma H., Yanofsky M.F., Meyerowitz E.M.
     Genes Dev. 5:484-495(1991).