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* Pancreatic hormone family signature *
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Pancreatic hormone (PP) [1] is a  peptide  synthesized in pancreatic islets of
Langherhans, which  acts    as  a regulator of pancreatic and gastrointestinal
functions.   A  number of other  active peptides  are homologous to pancreatic
hormone:

 - Neuropeptide Y (NPY)  [2],  one  of  the  most  abundant  peptides  in  the
   mammalian nervous system.  NPY is implicated in the control  of feeding and
   the secretion of the gonadotrophin-releasing hormone.
 - Peptide YY  (PYY)  [3].  PPY  is  a  gut  peptide  that  inhibits  exocrine
   pancreatic secretion, has a  vasoconstrictory  action  and inhibits jejunal
   and colonic mobility.
 - Various NPY and PYY-like polypeptides from fish and amphibians [4,5].

All  these  peptides  are  thirty  six  amino  acids  long.  Like  most active
peptides,  their C-terminal  is amidated  and  they are synthesized  as larger
protein  precursors.   The signature  for these  peptides is based on the last
twelve C-terminal residues, where five positions are completely conserved.

-Consensus pattern: [RQ]-x-Y-x-N-x-[LIVM]-T-R-x-R-[YF]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for pancreatic hormone from goose and from frogs.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Last update: December 1992 / Pattern and text revised.

[ 1] Blundell T.L., Humber R.E.
     Nature 287:781-787(1980).
[ 2] Allen J., Novotny J., Martin J., Heinrich G.
     Proc. Natl. Acad. Sci. U.S.A. 84:2532-2536(1987).
[ 3] Tatemoto K.
     Proc. Natl. Acad. Sci. U.S.A. 79:2514-2518(1982).
[ 4] Jensen J., Conlon J.M.
     Eur. J. Biochem. 210:405-410(1992).
[ 5] Conlon J.M., Chartrel N., Vaudry H.
     Peptides 13:145-149(1992).