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* Amino acid permeases signature *
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Amino acid permeases are integral  membrane proteins involved in the transport
of amino acids into the cell.  A number of such proteins have been found to be
evolutionary related [1,2,3]. These proteins are:

 - Yeast general amino acid permease (gene GAP1).
 - Yeast arginine permease (gene CAN1).
 - Yeast GABA permease (gene UGA4).
 - Yeast histidine permease (gene HIP1).
 - Yeast lysine permease (gene LYP1).
 - Yeast proline permease (gene PUT4).
 - Yeast choline transport protein (gene CTR1).
 - Yeast YCL25c, a hypothetical transport protein from chromosome III.
 - Yeast YKL174c, a hypothetical transport protein from chromosome XI.
 - Emericella nidulans proline transport protein (gene prnB).
 - Trichoderma harzianum amino acid permease INDA1.
 - Escherichia coli aromatic amino acid transport protein (gene aroP).
 - Escherichia coli GABA permease (gene gabP).
 - Escherichia coli lysine-specific permease (gene lysP).
 - Escherichia coli phenylalanine-specific permease (gene pheP).
 - Escherichia coli hypothetical protein yeeF.
 - Escherichia coli hypothetical protein yifK.

These proteins seem to contain up to 12 transmembrane segments. As a signature
for this family of proteins we selected  the  best  conserved region  which is
located in the second transmembrane segment.

-Consensus pattern: [STAGC]-G-P-x(2,3)-[LIVMFYW](2)-x-[LIVMFYW]-x-
                    [LIVMFSTA](2)-[SAG]-x(3)-[LIVMFYW]-x-[LIVMS]-x(3)-[LMC]-
                    [GA]-E-x(5)-[PS]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for yeeF.
-Other sequence(s) detected in SWISS-PROT: NONE.
-Last update: June 1994 / Pattern and text revised.

[ 1] Weber E., Chevalier M.R., Jund R.
     J. Mol. Evol. 27:341-350(1988).
[ 2] Vandenbol M., Jauniaux J.-C., Grenson M.
     Gene 83:153-159(1989).
[ 3] Reizer J., Finley K., Kakuda D., McLeod C.L., Reizer A., Saier M.H. Jr.
     Protein Sci. 2:20-30(1993).