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* E1-E2 ATPases phosphorylation site *
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E1-E2 ATPases are cation transport  ATPases which  form  an aspartyl phosphate
intermediate in  the  course  of  ATP hydrolysis. ATPases which belong to this
family are listed below [1,2,3].

 - Fungal and plant plasma membrane (H+) ATPases [reviewed in 3].
 - Vertebrate (Na+, K+) ATPases (sodium pump) [reviewed in 5,6].
 - Gastric (K+, H+) ATPases (proton pump).
 - Calcium (Ca++) ATPases (calcium pump) from the sarcoplasmic reticulum (SR),
   the endoplasmic reticulum (ER) and the plasma membrane.
 - Copper (Cu++) ATPases (copper pump) which are involved in two human genetic
   disorders: Menkes syndrome and Wilson disease [7].
 - Bacterial potassium (K+) ATPases.
 - Bacterial cadmium efflux (Cd++) ATPases [reviewed in 8].
 - Bacterial magnesium (Mg++) ATPases [9].
 - A probable cation ATPase from Leishmania.
 - fixI,  a  probable  cation  ATPase    from  Rhizobium meliloti, involved in
   nitrogen fixation.

The region  around the phosphorylated aspartate residue is perfectly conserved
in all these ATPases and can be used as a signature pattern.

-Consensus pattern: D-K-T-G-T-[LIVM]-[TI]
                    [D is phosphorylated]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in SWISS-PROT: Staphylococcus  aureus  DNA  gyrase
 subunit B.
-Last update: June 1994 / Pattern and text revised.

[ 1] Green N.M., McLennan D.H.
     Biochem. Soc. Trans. 17:819-822(1989).
[ 2] Green N.M.
     Biochem. Soc. Trans. 17:970-972(1989).
[ 3] Fagan M.j., Saier M.H. Jr.
     J. Mol. Evol. 38:57-99(1994).
[ 4] Serrano R.
     Biochim. Biophys. Acta 947:1-28(1988).
[ 5] Fambrough D.M.
     Trends Neurosci. 11:325-328(1988).
[ 6] Sweadner K.J.
     Biochim. Biophys. Acta 988:185-220(1989).
[ 7] Bull P.C., Thomas G.R., Rommens J.M., Forbes J.R., Cox D.
     Nature Genet. 5:327-337(1993).
[ 8] Silver S., Nucifora G., Chu L., Misra T.K.
     Trends Biochem. Sci. 14:76-80(1989).
[ 9] Snavely M.D., Miller C.G., Maguire M.E.
     J. Biol. Chem. 266:815-823(1991).