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In an early number theory paper he proved that there is no odd perfect number with fewer than four distinct prime factors. He also revised and wrote a commentary on Bowditch's translation of the first four volumes of Laplace's Traité de mécanique céleste .
Appointed professor at Harvard in 1833 he was to establish the Harvard Observatory. Peirce helped determine the orbit of Neptune (discovered in 1846) and calculated the perturbations produced by Neptune on the orbit of Uranus and on the other planets.
In 1870 Peirce published, at his own expense, Linear Associative Algebra a classification of all complex associative algebras of dimension less than seven. He used the, now familiar, tools of idempotent and nilpotent elements.
Earlier, in 1852, Peirce had introduced methods into the theory of errors applied to observations which would allow faulty observations to be discarded.
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