1834-1914. German biologist. His failing eyesight forced him to turn from microscopy to theoretical work. In 1892 he proposed that changes to the body do not in turn cause an alteration of the genetic material. This `central dogma' of biology remains of vital importance to biologists supporting the Darwinian theory of evolution. If the genetic material can be altered only by chance mutation and recombination, then the Lamarckian view that acquired bodily changes can subsequently be inherited becomes obsolete.