c. 358-280 BC. Macedonian general under Alexander the Great and founder of the Seleucid Empire. After Alexander's death 323 BC, Seleucus became governor and then (312 BC) ruler of Babylonia, founding the city of Seleucia on the river Tigris. He conquered Syria and had himself crowned king 306 BC, but his expansionist policies brought him into conflict with the Ptolemies of Egypt, and he was assassinated by Ptolemy Ceraunus. He was succeeded by his son Antiochus I.