Industrial city (textiles, chemicals, machinery, printing) and capital of Rhone departement, Rhone-Alpes region, and third largest city of France, at the confluence of the Rhone and Saone rivers, 275 km/170 mi NNW of Marseille; population (1982) 418,476, conurbation 1,221,000. Formerly a chief fortress of France, it was the ancient Lugdunum, taken by the Romans 43 bc.