1906-1979. German-born British biochemist who worked on the development of penicillin. Chain fled to Britain from the Nazis 1933. After the discovery of penicillin by Alexander Fleming, Chain worked to isolate and purify it. For this work, he shared the 1945 Nobel Prize for Medicine with Fleming and Howard Florey. Chain also discovered penicillinase, an enzyme that destroys penicillin.