Common manifestation of dementia, thought to afflict one in 20 people over 65. Attacking the brain's `grey matter', it is a disease of mental processes rather than physical function, characterized by memory loss and progressive intellectual impairment. It was first described by Alois Alzheimer 1906. The cause is unknown, although a link with high levels of aluminium in drinking water was discovered 1989. It has also been suggested that the disease may result from a defective protein circulating in the blood. There is no treatment, but recent insights into the molecular basis of the disease may aid the search for a drug to counter its effects.