The Amigaport V1.26 of GNUEmacs has a annoying bug; it quotes all arguments to commands, therefore RX can't be called directly. A workaround is to specify rexx-command-name to "rxnq", which is a small (280 bytes!) command which strips the quotes and calls RX. To do this, place the following lines into the rxdb-mode-hook is the s:.emacs file. (setq rxdb-command-name "rxnq") And place rxnq in the loadpath.